Phagocytosis can be viewed as a primitive immune system used by all cells. When a pathogen is near the cell, the cell membrane will deform to engulf the pathogen and dispose of it. Researchers have found that a two-dimensional sheet formed by the protein GAS7 is critical for this process, identifying through crystallography and microscopy two key hydrophilic loops in the protein.
Read moreThe study, conducted in mice, is the first to show that creatine uptake is critical to the anti-tumor activities of killer T cells, the foot soldiers of the immune system.
Read moreResearchers have developed a new cheap method that can identify highly heterogeneous tumors that tend to be very aggressive, and therefore need to be treated more aggressively.
Read moreA compound effective in killing chemotherapy-resistant glioblastoma-initiating cells (GICs) has been identified, raising hopes of producing drugs capable of eradicating refractory tumors with low toxicity.
Read moreResearchers have identified a targeted therapy for adolescent patients with neuroblastoma, a deadly pediatric nerve cancer, who would otherwise have no treatment options, according to a new study.
Read moreFor the first time, researchers have created mouse blastocyst-like structures, or 'blastoids,' from a single cultured cell. The work could help advance research into development as well as inform issues around pregnancy, infertility, or health problems later in the offspring's life.
Read moreResearchers report they have obtained 3D structural snapshots of Cdc34 in action. Cdc34 is an enzyme important for cell cycle regulation and a target for therapeutic intervention in cancer. These structures, along with studies in human cells, have revealed key features of this enzyme important for its regulation of cell growth and activity. These unique features could present opportunities for rational design of novel cancer therapeutics.
Read moreA new article compares cancer detection rates (CDR) for screening digital breast tomosynthesis (DBT) versus full-field digital mammography (FFDM). Researchers found that DBT results in 'significantly increased CDR' — irrespective of tumor type, size, or grade of cancer.
Read moreFor the rising number of cancer survivors worldwide, there's growing evidence that exercise is an important part of recovery. But how much, and what type of exercise, is needed?
Read moreResearchers clarify mechanisms that allow hard-to-treat cancers to develop, and have identified strategies that could lead to new therapies.
Read more