Aggressive form of breast cancer influenced by dual action of genes and RNA

Women with an aggressive, less-common type of breast cancer, known as triple-negative, versus a more common form of the disease, could be differentiated from each other by a panel of 17 small RNA molecules that are directly influenced by genetic alterations typically found in cancer cells.

Read more

New insights into the structure and function of Cdc34, a target for cancer therapeutics

Researchers report they have obtained 3D structural snapshots of Cdc34 in action. Cdc34 is an enzyme important for cell cycle regulation and a target for therapeutic intervention in cancer. These structures, along with studies in human cells, have revealed key features of this enzyme important for its regulation of cell growth and activity. These unique features could present opportunities for rational design of novel cancer therapeutics.

Read more

Viagra shows promise for use in bone marrow transplants

Researchers have demonstrated a new, rapid method to obtain donor stem cells for bone marrow transplants using a combination of Viagra and a second drug called Plerixafor. Bone marrow transplants, used mostly in the treatment of cancer, are life-saving procedures to restore the stem cells that generate new blood cells throughout a person's life.

Read more

First cell map of developing human liver reveals how blood and immune system develops

In a world first, scientists have created the human developmental liver cell atlas that provides crucial insights into how the blood and immune systems develop in the fetus. It maps changes in the cellular landscape of the developing liver between the first and second trimesters of pregnancy, including how stem cells from the liver seed other tissues to support the high demand for oxygen needed for growth.

Read more