How common genetic mutation drives cancer
A new, multicenter study has determined how a single mutation in splicing factor 3b subunit 1 (SF3B1), the most frequently mutated splicing factor gene, drives the formation of many cancers.
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'Wild idea' opens possible new frontier for preventing ovarian cancer
A laboratory study offers a new hypothesis about how ovarian cancer forms and suggests how it might be prevented. The study is the first to show that the natural stiffening of the ovaries called fibrosis occurs with age. It also suggests that the diabetes drug metformin may be able to halt this process.
Read morePotential liver cancer treatment by targeting cancer stem-like cells
Researchers have shown the potential use of small molecule inhibitors to treat advanced liver cancer.
Read moreInnovative pancreatic cancer treatment may rev up immune system
A research team reports that combining a type of radiation therapy with immunotherapy not only cures pancreatic cancer in mice, but appears to reprogram the immune system to create an 'immune memory' in the same way that a vaccine keeps the flu away. The result is that the combination treatment also destroyed pancreatic cells that had spread to the liver, a common site for metastatic disease.
Read moreInsights on treatment and prognosis of male breast cancer
A recent analysis reveals that treatment of male breast cancer has evolved over the years. In addition, certain patient-, tumor-, and treatment-related factors are linked with better survival.
Read moreLymphoma stage at diagnosis may predict when and where new cancer forms
A new study shows the stage at which lymphoma is originally diagnosed impacts the types of second cancers that may form after treatment.
Read moreMapping normal breast development to better understand cancer
Breast cancer is one of the most prevalent cancers, and some forms rank among the most difficult to treat. Its various types and involvement of many different cells makes targeting such tumors difficult. Now, researchers have used a state-of-the-art technology to profile each cell during normal breast development in order to understand what goes wrong in cancer.
Read moreScientists have identified the presence of cancer-suppressing cells in pancreatic cancer
Researchers have identified cells containing a protein called Meflin that has a role in restraining the progression of pancreatic cancer. They have also shown that cancer progression can be controlled by artificially increasing the amount of this protein in the cells.
Read moreThe story of thalidomide continues
An international study has unveiled a detailed view of how thalidomide, one of the most notorious drugs ever developed, causes abnormalities in limb and ear development. The findings may contribute to the re-emergence of safe, or non-teratogenic, thalidomide-derived drugs as a treatment for cancer and inflammatory diseases.
Read moreMeningioma molecular profile reliably predicts tumor recurrence
Researchers report tumor's molecular profiles that might better predict meningioma recurrence.
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