Drug treats inflammation associated with genetic heart disease

When young athletes experiences sudden cardiac death as they run down the playing field, it's usually due to arrhythmogenic cardiomyopathy (ACM), an inherited heart disease. Now, researchers have shed new light on the role of the immune system in the progression of ACM and, in the process, discovered a new drug that might help prevent ACM disease symptoms and progression to heart failure in some patients.

Read more

New effective vaccines for Lyme disease are coming

There is no effective vaccine currently available to prevent Lyme disease in humans. Experts from academia, government, and industry recently convened to tackle this public health challenge. Now, a new article reiterates the need to stop the infection, and defines a strategy for developing effective vaccines.

Read more

Failure of mitochondrial quality control causes heart disease

Mutations in the gene that encodes a protein called ANT cause a variety of conditions, such as heart disease, but the underlying mechanism of how these mutations trigger disease has been unclear. Researchers discovered that ANT is critical for a quality control process called mitophagy — which helps to ensure the integrity of the mitochondria network — and found that mutations that lead to a defective quality control system cause heart disease.

Read more