Your healthcare provider's expectations on whether a treatment works may impact its effectiveness

If a doctor expects a treatment to be successful, a patient may experience less pain and have better outcomes, according to a new study. The findings reveal how social interactions between hypothetical healthcare providers and patients have the power to influence how patients perceive the effectiveness of a treatment, even when it is a placebo.

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Young adults with PTSD may have a higher risk of stroke in middle age

Young adults who develop PTSD after a traumatic event (e.g., gun violence, sexual assault, military combat or natural disaster) may be more likely to experience a transient ischemic attack (TIA) or major stroke event by middle age. This nationwide study of more than 1.1 million adults showed that PTSD may be a potent risk factor for developing stroke at a young age.

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Protein misfolding as a risk marker for Alzheimer's disease

In symptom-free individuals, the detection of misfolded amyloid-beta protein in the blood indicated a considerably higher risk of Alzheimer's disease — up to 14 years before a clinical diagnosis was made. Amyloid-beta folding proved to be superior to other risk markers evaluated.

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Changes associated with Alzheimer's disease detectable in blood samples

Researchers have discovered new changes in blood samples associated with Alzheimer's disease. A new international study was conducted on disease-discordant Finnish twin pairs: one sibling suffering from Alzheimer's disease and the other being cognitively healthy. The researchers utilised the latest genome-wide methods to examine the twins' blood samples for any disease-related differences in epigenetic marks which are sensitive to changes in environmental factors. These differences between the siblings were discovered in multiple different genomic regions.

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Opioid Rx dosages drop with state law changes

The total amount of opioids dispensed per new opioid prescription decreased by 22% in Penn Medicine outpatient practices in New Jersey after the state passed a law limiting prescriptions to a five-day supply for new opioid prescriptions. Penn Medicine implemented an electronic health record (EMR) alert, or 'nudge,' to notify clinicians if that limit had been reached.

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