Schizophrenia risk gene linked to cognitive deficits in mice

Researchers have discovered in mice how one of the few genes definitively linked to schizophrenia, called SETD1A, likely confers risk for the illness. Mice genetically engineered to lack a functioning version of the enzyme-coding gene showed abnormalities in working memory, mimicking those commonly seen in patients. Restoring the gene's function corrected the working memory deficit and counteracting its deficiency also repaired neuronal circuit deficits in adult mice — suggesting clues for potential treatment strategies.

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E-cigarette flavors decrease perception of harm among youth

As more and more youth use electronic cigarettes, combined with research showing the health consequences of vaping — including nicotine addiction — researchers found that non-menthol flavors attract youth and adults to use e-cigarettes and that the use of flavored e-cigarettes contributes to multiple pathways linked to higher e-cigarette use among youth.

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The long arm of childhood conditions

Available research on the impact of a person's socioeconomic status during childhood suggests that the circumstances one grows up in matter a great deal for adult health. The results of a new study supports the notion of a 'long arm of childhood conditions' that remains invisible beyond mid-life but can affect health satisfaction later in life.

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No link found between youth contact sports and cognitive, mental health problems

Adolescents who play contact sports, including football, are no more likely to experience cognitive impairment, depression or suicidal thoughts in early adulthood than their peers, suggests a new study of nearly 11,000 youth followed for 14 years.

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Young adults with PTSD may have a higher risk of stroke in middle age

Young adults who develop PTSD after a traumatic event (e.g., gun violence, sexual assault, military combat or natural disaster) may be more likely to experience a transient ischemic attack (TIA) or major stroke event by middle age. This nationwide study of more than 1.1 million adults showed that PTSD may be a potent risk factor for developing stroke at a young age.

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New insights into biological underpinnings of schizophrenia

Researchers have implicated 10 new genes in the development of schizophrenia using a method called whole exome sequencing, the analysis of the portion of DNA that codes for proteins. A global consortium of schizophrenia research teams incorporated genetic data from over 125,000 people to gain deeper insights into the genetic underpinnings of schizophrenia.

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