Gene Therapy – PossibleThreat Articles

Schizophrenia risk gene linked to cognitive deficits in mice

October 24, 2019 0 Comments Disorders and Syndromes, Gene Therapy, Genes, Memory, Mental Health, Mental Health Research, Personalized Medicine, Schizophrenia

Researchers have discovered in mice how one of the few genes definitively linked to schizophrenia, called SETD1A, likely confers risk for the illness. Mice genetically engineered to lack a functioning version of the enzyme-coding gene showed abnormalities in working memory, mimicking those commonly seen in patients. Restoring the gene's function corrected the working memory deficit and counteracting its deficiency also repaired neuronal circuit deficits in adult mice — suggesting clues for potential treatment strategies.

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Researchers quantify Cas9-caused off-target mutagenesis in mice

October 19, 2019 0 Comments Biochemistry, CRISPR Gene Editing, Gene Therapy, Genes, Genetically Modified, mice, Microarrays, Organic Chemistry, Personalized Medicine

Scientists are finding new ways to improve the use of the CRISPR enzyme Cas9 and reduce the chances of off-target mutations in laboratory mice, according to new results. The findings will help scientists contextualize a common concern related to gene editing and identify new strategies to improve its precision.

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'Flamenco dancing' molecule could lead to better-protecting sunscreen

October 19, 2019 0 Comments Chemistry, Gene Therapy, Inorganic Chemistry, Optics, Skin Cancer, Skin Care, Thermodynamics, Vitamin D

A molecule that protects plants from overexposure to harmful sunlight thanks to its flamenco-style twist could form the basis for a new longer-lasting sunscreen, chemists have found.

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When added to gene therapy, plant-based compound may enable faster, more effective treatments

October 17, 2019 0 Comments Anemia, Gene Therapy, Immune System, Lymphoma, Medical Topics, Prostate Cancer, Skin Cancer, Stem Cells

Today's standard process for administering gene therapy is expensive and time-consuming — a result of the many steps required to deliver the healthy genes into the patients' blood stem cells to correct a genetic problem. Scientists believe they have found a way to sidestep some of the current difficulties, resulting in a more efficient gene delivery method that would save money and improve treatment outcomes.

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Daily exposure to blue light may accelerate aging, even if it doesn't reach your eyes

October 17, 2019 0 Comments Brain Injury, Communications, Dementia, Gene Therapy, Healthy Aging, Intelligence, Mobile Computing, Neural Interfaces, Vitamin D

Prolonged exposure to blue light, such as that which emanates from your phone, computer and household fixtures, could be affecting your longevity, even if it's not shining in your eyes. New research suggests that the blue wavelengths produced by light-emitting diodes damage cells in the brain as well as retinas, according to a new study in a model organism.

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Computational 'match game' identifies potential antibiotics

October 16, 2019 0 Comments Biology, Gene Therapy, Genes, Genetics, Human Biology, Medical Topics, Microbes and More, New Species

Computational biologists have devised a software tool that can play a high-speed 'Match Game' to identify bioactive molecules and the microbial genes that produce them so they can be evaluated as possible antibiotics and other therapeutic agents.

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From ribbon to scroll: Gaining shape control by electrostatics

October 16, 2019 0 Comments Civil Engineering, Engineering, Engineering and Construction, Gene Therapy, Genes, Medical Topics, Organic Chemistry, Pharmacology

New insights into how the molecular organization of charged molecules can be regulated to transform large-scale structures from ribbons to scroll-like cochleate structures could inform future drug-delivery strategies.

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In-office gene therapy for wet age-related macular degeneration is coming

October 12, 2019 0 Comments Birth Defects, Diseases and Conditions, Eye Care, Gene Therapy, Genes, Medical Topics, Personalized Medicine, Wounds and Healing

Gene therapy is showing promise for one of the most common causes of blindness.

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Sox9 reshapes the biliary tree in Alagille syndrome

October 11, 2019 0 Comments Birth Defects, Children's Health, Chronic Illness, Diseases and Conditions, Down Syndrome, Gene Therapy, Liver Disease, Today's Healthcare

Mose model shows that SOX9 gene influences the severity Alagille syndrome.

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Powerful new genomics method can be used to reveal the causes of rare genetic diseases

October 11, 2019 0 Comments Diseases and Conditions, Gene Therapy, Genes, Human Biology, Microarrays, Organic Chemistry, Physics, Sports Science

The technique makes use of the fact that people inherit two copies or ''alleles'' of virtually every gene, one from the mother and one from the father. The new method compares activity levels of maternal and paternal alleles across the genome and detects when the activity of an allele lies far enough outside the normal range to be a plausible cause of disease.

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