Scientists have discovered that cancer uses a hidden hormone to switch off the body’s natural defenses, allowing tumors to grow unchecked. By uncovering this secret signal, they found a way to block it and restore the immune system’s ability to fight back. The breakthrough not only hints at powerful new cancer treatments but also suggests the same pathway could someday be used to calm autoimmune diseases.
Read moreMayo Clinic scientists uncovered how excessive drinking triggers fatty liver disease by disrupting the enzyme VCP, which normally prevents harmful protein buildup on fat droplets in the liver. Alcohol blocks this protective process, allowing fat to accumulate and damage liver cells.
Read moreResearchers have identified a potential approach to stop the growth of the most common type of brain tumor in children.
Read moreResearchers have uncovered new details about several proteins implicated in tumor growth and metastasis, opening a potential avenue for the development of treatments for diseases such as breast cancer.
Read moreResearchers report a discovery that helps scientists understand why some tumors lack immune cell infiltration and are therefore unresponsive to newer PD-1 targeted therapies.
Read moreA new study indicates a way for cancer immunotherapy to spur a more robust immune response. Such knowledge could lead to the development of better cancer vaccines and more effective immunotherapy drugs called checkpoint inhibitors.
Read moreNew research shows that lactate, an end product of metabolism, changes the function of an immune cell known as a macrophage, thereby rewiring it to behave differently.
Read moreWhether it's chocolate cake or pasta sauce, the sensation of sweetness plays a major role in the human diet and the perception of other flavors. While a lot is known about the individual proteins that signal ''sweet,'' not much is known about how the proteins work together as a receptor to accomplish this feat.
Read moreA new study reports how an experimental drug agent stops cancer cells from growing. A little over a decade ago, scientists first reported pentagamavumon-1 (PGV-1), an analogue of a molecule found in turmeric and that has been since discovered to have anti-cancer effects. In the new study, tests on cancer cells and animals reveal that these anti-cancer effects come from PGV-1 inhibiting a series of enzymes responsible for the metabolism of reactive oxygen species. This finding is expected to clarify how modifications to PGV-1 will lead to its use for cancer treatment.
Read moreTissue patterning is an important process during embryo formation, which ensures that groups of cells are arranged in an appropriate manner that allows them to function properly.
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