Newly discovered protein is the permit to the powerhouse of cells

Researchers report the discovery of a protein, P17/PERMIT, that is key to recycling aging and damaged mitochondria. Defective mitochondria are characteristic of a number of age-related diseases, including cancer and Alzheimer's. The MUSC team showed P17/PERMIT transports the machinery that produces ceramide, a molecule that signals old mitochondria for destruction, to the mitochondria. There, it can mass-produce ceramide at the location needed for mitochondrial regulation.

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Reduced food intake in old mice can no longer improve health

Reduced food intake helps both animals and humans to improve health in old age and can prolong life. But when do you have to change your diet to achieve this benefit in old age? Scientists have now shown that mice only become healthier if they start food reduction early and eat less before entering old age. The scientists conclude that healthy behavior must be established earlier in life in order to improve health in old age and extend lifespan.

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Exploring the effect of fasting on age-related diseases

There are many indications that fasting promotes longevity. In recent years, much attention has been devoted to so-called caloric restriction mimetics (CMRs), substances that simulate the health-promoting effects of fasting without the need of life-style change. A study reports the identification of a novel candidate CRM. The substance may prove useful in the further research for the treatment of age-related diseases.

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