Swapping a single amino acid in a simple bacterial protein changes its structure and function, revealing the effects of complex gene evolution, finds a new study. The study — conducted using E. coli bacteria — can help researchers to better understand the evolution of transporter proteins and their role in drug resistance.
Read moreFrench investigators have described development of resistance to one of the last resort therapies used to treat extremely drug-resistant Pseudomonas aeruginosa. That resistance arose in a single patient over a scant 22 days. They subsequently identified the single nucleotide mutation in P. aeruginosa that caused the resistance.
Read moreA study has revealed a protein's role in helping bacteria 'reel in' DNA from their environment to acquire new traits, such as antibiotic resistance.
Read moreOrganic chemists have figured out how to synthesize the most common molecule arrangement in medicine, a scientific discovery that could change the way a number of drugs — including one most commonly used to treat ovarian cancer — are produced. Their discovery, published today in the journal Chem, gives drug makers a crucial building block for creating medicines that, so far, are made with complex processes that result in a lot of waste.
Read moreViruses are non-living creatures, consisting of genetic material encased in a protein coat. Once the virus infects a living organism, it can replicate itself and continue on. But what happens if a virus lacks the proper tools to infect an organism? How can it propagate? Researchers have uncovered a novel virus that may help answer those questions.
Read moreResearchers have developed a machine learning system that may be able to warn doctors and patients about possible negative side effects that might occur when drugs are mixed.
Read moreResearchers report that the injectable hormone tesamorelin reduces liver fat and prevents liver fibrosis (scarring) in people living with HIV.
Read moreResearchers have now turned a CRISPR RNA-cutting enzyme into an antiviral that can be programmed to detect and destroy RNA-based viruses in human cells.
Read moreIn animals, infections are fought by the immune system. Studies on an unusual virus infecting wild koalas, by a team of researchers reveal a new form of "genome immunity."
Read moreResearchers report that the growing appetite for animal protein in low- to middle-income countries has resulted in a smorgasbord of antibiotic consumption for livestock that has nearly tripled the occurrence of antibiotic resistance in disease-causing bacteria between 2000 and 2018. The researchers found that antibiotic resistance in livestock was most widespread in China and India, with Brazil and Kenya emerging as new hotspots.
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