For the first time, researchers have learned at the molecular level how the P2X7 protein receptor – which is associated with inflammation, coronary artery disease, cancer, multiple sclerosis and more – works. The findings could one day inspire new drugs to treat numerous medical conditions.
Read moreHead and neck melanoma among pediatric, adolescent and young adult populations in the United States and Canada increased by 51.1% from 1995 to 2014.
Read moreCurrent biology research relies on the ability to purify cell types using antibodies or transgenic constructs. However, antibody availability is often limited, and genetic manipulation is labor intensive or sometimes impossible. To date, no universal method exists to enrich for cell types without a priori knowledge of cell type markers. Here, we propose GateID, a computational method that combines single-cell transcriptomics with FACS index sorting to purify cell types using only native cellular properties.
Read moreResearchers have developed an innovative drug treatment for familial adenomatous polyposis (FAP), a rare, inherited condition that affects adolescents and young adults and often leads to colorectal cancer.
Read moreA research team has discovered a metabolic vulnerability in multiple types of cancer cells that bear a common genetic mutation affecting cellular machines called spliceosomes.
Read moreRoutine testing for bowel cancer should not be recommended for everyone aged 50-79 years because, for those at very low risk, the benefit is small and uncertain and there are potential harms, say a panel of international experts.
Read moreInvestigators analyzed 40 years of cancer burden data and examined patterns of incidence and mortality for various cancers, finding examples for which incidence and mortality moved in concert and examples where discordance in incidence and mortality indicate that overdiagnosis may be at play.
Read moreCertain fungi move from the gut to the pancreas, expand their population more than a thousand-fold, and encourage pancreatic cancer growth, a new study finds.
Read moreA new 3D structure for growing cell cultures could enable doctors to test medications on model tumors grown from a patient's own cells, according to a team of engineers and cancer researchers.
Read morePhorbiplatin is a new anti-cancer prodrug that can be controllably activated by red light. With its unique 'on-site' activation characteristic, this new prodrug can effectively kill cancer cells and minimize damage to normal tissues.
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