Important questions on how mental illness is currently diagnosed

This research raises questions as to whether current diagnoses accurately reflect the underlying neurobiology of mental illness. The findings, just published in the leading peer-reviewed medical journal, JAMA Psychiatry, highlight the need for more individualised approaches to defining mental illness.

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Vaping-associated lung injury findings

A clinical perspective article reviews various imaging manifestations of electronic nicotine delivery systems such as e-cigarettes, vape pens, and hookah tanks. Despite the lack of a standardized case definition for vaping-associated lung injury, the radiologist may be the first person to prompt the clinical team to ask about relevant exposures like hypersensitivity pneumonitis, diffuse alveolar hemorrhage, acute eosinophilic pneumonia, organizing pneumonia, lipoid pneumonia, and giant cell interstitial pneumonia.

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'Wild idea' opens possible new frontier for preventing ovarian cancer

A laboratory study offers a new hypothesis about how ovarian cancer forms and suggests how it might be prevented. The study is the first to show that the natural stiffening of the ovaries called fibrosis occurs with age. It also suggests that the diabetes drug metformin may be able to halt this process.

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Fruit flies help in the development of personalized medicine

It is common knowledge that there is a connection between our genes and the risk of developing certain diseases. In a study on fruit flies, researchers have found that gene mapping can also be used to predict response to a given treatment. This knowledge is crucial for the development of personalized medicine.

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Paclitaxel-coated devices are safe for unblocking arteries in lower limbs, study suggests

A study of nearly 65,000 people suggests that devices coated with a drug called paclitaxel that are used for widening blocked arteries in legs and feet are safe and not linked to an increase in deaths — a finding that contradicts smaller studies that led to the FDA issuing a safety alert about the use of paclitaxel-coated stents and balloons for arterial revascularization in the lower limbs in January 2019.

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Innovative pancreatic cancer treatment may rev up immune system

A research team reports that combining a type of radiation therapy with immunotherapy not only cures pancreatic cancer in mice, but appears to reprogram the immune system to create an 'immune memory' in the same way that a vaccine keeps the flu away. The result is that the combination treatment also destroyed pancreatic cells that had spread to the liver, a common site for metastatic disease.

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