Machine learning's next frontier: Epigenetic drug discovery

Scientists have developed a machine-learning algorithm that gleans information from microscope images — allowing for high-throughput epigenetic drug screens that could unlock new treatments for cancer, heart disease, mental illness and more.

Read more

Histone modifications are the influencers of zygotic genome awakening

Scientists have observed changes to the gene-regulating factors during zebrafish development and discovered that modifications to 'histone H3', one of the proteins around which DNA is bound, play an important role in 'zygotic genome activation' or transition of control of zebrafish embryonic development from maternal material to the zygote.

Read more

Scientists ID new targets to treat fibrosis, a feature of many chronic diseases

When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term — but bad when myofibroblast activation gets out of hand. Now, researchers show how fibroblast activation and myofibroblast formation occurs, providing clues for how to target fibrosis — which impacts several chronic diseases.

Read more