Consuming alcohol leads to epigenetic changes in brain memory centers

New research revealed a surprising pathway that shows alcohol byproducts travel to the brain to promote addiction memory. They show how acetate travels to the brain's learning system and directly alters proteins the regulate DNA function, impacting how some genes are expressed and ultimately affecting how mice behave when given environmental cues to consume alcohol.

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Protein in blood protects against neuronal damage after brain hemorrhage

Patients who survive a cerebral hemorrhage may suffer delayed severe brain damage caused by free hemoglobin, which comes from red blood cells and damages neurons. Researchers have now discovered a protective protein in the body called haptoglobin, which prevents this effect.

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A blood factor involved in weight loss and aging

Aging can be delayed through lifestyle changes (physical exercise, restricting calorie intake, etc.). Researchers have elucidated the properties of a molecule in the blood – GDF11 – whose mechanisms were previously unknown. In a mouse model, they showed that this molecule could mimic the benefits of certain calorie restrictions – dietary regimens that have proven their efficacy in reducing cardiovascular disease, preventing cancer and increasing neurogenesis in the brain.

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How the brain dials up the volume to hear someone in a crowd

Our brains have a remarkable ability to pick out one voice from among many. Now, a team has uncovered the steps that take place in the brain to make this feat possible. Today's discovery helps to solve a long-standing scientific question as to how the brain's listening center can decode and amplify one voice over others. It also stands to spur development of hearing-aid technologies and brain-computer interfaces that more closely resemble the brain.

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Gene variants influence size of brainstem, other structures

Three-hundred researchers have identified 48 common genetic variants that are associated with the size of the brainstem and other subcortical structures deep within the brain. This is the first step toward understanding how to devise treatments for disorders affecting these structures.

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