Cambridge scientists created a gel that could end arthritis pain

Cambridge scientists have created a breakthrough material that can sense tiny chemical changes in the body, such as the increased acidity during an arthritis flare-up, and release drugs exactly when and where they’re needed. By mimicking cartilage while delivering medication, this smart gel could ease pain, reduce side effects, and provide continuous treatment for millions of arthritis sufferers.

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Simple therapies outperform drugs for knee arthritis pain relief

A sweeping analysis of nearly 10,000 patients reveals that knee braces, hydrotherapy, and exercise stand out as the most effective non-drug therapies for knee osteoarthritis. Unlike common pain medications that carry risks, these low-cost and accessible options reduce pain, improve mobility, and could shift treatment guidelines toward safer, drug-free approaches.

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Protective mediators can help heal injured tendon cells by attacking inflammation

Tendon tears, both to the rotator cuff and Achilles heel, are common injuries, especially in aged individuals. Painful and disabling, they can adversely impact quality of life. New approaches are required to help patients suffering from chronic tendon injuries. A novel study identified mediators that promote resolution of inflammation as potential new therapeutics to push chronically injured tendons down an inflammation-resolving pathway.

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Large genome-wide association study illuminates genetic risk factors for gout

Researchers, using a method called genome-wide association study, have illuminated the genetic underpinnings of high serum urate, the blood condition that brings on gout. The study will inform efforts to develop screening tests for gout risk as well as potential new treatments.

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