Leukemia drug shows promise for treating a childhood brain cancer
Researchers describe a new use of leukemia drug, nilotinib, to treat a subtype of medulloblastoma, a deadly pediatric brain cancer.
Read moreLung Cancer
Novel regulator of mitochondrial cell death reveals a promising target for cancer therapy
Researchers have described the role of mitochondrial fission factor (MFF) in controlling survival of cancer cells, suggesting the protein could represent a promising therapeutic target.
Read moreEvidence underpinning approval of new cancer drugs raises questions
Around half of trials that supported new cancer drug approvals in Europe between 2014 and 2016 were judged to be at high risk of bias, which indicates that treatment effects might have been exaggerated, concludes a new study.
Read moreCombination therapies could help treat fatal lung cancers
Combining a new class of drug with two other compounds can significantly shrink lung tumors in mice and human cancer cells, new research shows. The study looked at G12C KRAS inhibitors, a new type of drug that targets a specific mutation that can cause cells to multiply uncontrollably and lead to fast-growing cancers.
Read moreNew drug target in fight against cancer
Researchers have discovered how a cancer-linked version of the protein mitoNEET can close voltage-dependent anion channels (VDAC), primary gateways in the outer surface of mitochondria. The researchers detail how mitoNEET regulates VDAC, and they show that the interactions between the two proteins could be disrupted by a drug that targets VDAC.
Read moreBrain tumors form synapses with healthy neurons
Scientists have shown for the first time that severe brain cancers integrate into the brain's wiring.
Read moreCancer cells turn to cannibalism to survive chemotherapy, study suggests
Researchers have discovered that some cancer cells survive chemotherapy by eating their neighboring tumor cells. The study suggests that this act of cannibalism provides these cancer cells with the energy they need to stay alive and initiate tumor relapse after the course of treatment is completed.
Read morePsoriasis drug target offers potential for osteosarcoma
A treatment for psoriasis could be repurposed to treat a rare but aggressive form of youth cancer, new findings suggest.
Read moreKidney disease: Senescent cell burden is reduced in humans by senolytic drugs
In a small safety and feasibility clinical trial, researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed 'senolytics.' The result was verified not only in analysis of blood but also in changes in skin and fat tissue senescent cell abundance.
Read moreElectronic nose can sniff out which lung cancer patients will respond to immunotherapy
An electronic nose that detects chemicals in the breath of lung cancer patients can identify with 85% accuracy those who will or will not respond to immunotherapy, according to new research.
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