Brain fat, not just plaques, may be the hidden driver of Alzheimer’s

For decades, scientists believed Alzheimer’s was driven mainly by sticky protein plaques and tangles in the brain. Now Purdue researchers have revealed a hidden culprit: fat. They found that brain immune cells can become clogged with fat, leaving them too weak to fight off disease. By clearing out this fat and restoring the cells’ defenses, researchers may have uncovered an entirely new way to combat Alzheimer’s — shifting the focus from plaques alone to how the brain handles fat.

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Scientists reveal pill that helps shed 20% of body weight

A massive international study has shown that the experimental oral obesity drug orforglipron can help patients shed over 10% of their body weight, with nearly one in five losing 20% or more. Unlike most GLP-1 agonists that require injections, orforglipron comes as a once-daily pill, potentially making weight-loss treatment more accessible.

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A rogue black hole is beaming energy from a nearby dwarf galaxy

Astronomers detected a black hole displaced nearly a kiloparsec from the center of a dwarf galaxy 230 million light-years away. Unlike most, it is actively feeding and producing radio jets, making it one of the most convincing off-nuclear cases ever confirmed. The discovery reveals that black holes can grow and shape galaxies even when not in the core, reshaping theories of cosmic evolution.

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The phantom heat of empty space might soon be detectable

A Hiroshima University team has designed a feasible way to detect the Unruh effect, where acceleration turns quantum vacuum fluctuations into observable particles. By using superconducting Josephson junctions, they can achieve extreme accelerations that create a detectable Unruh temperature. This produces measurable voltage jumps, providing a clear signal of the effect. The breakthrough could transform both fundamental physics and quantum technology.

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This forgotten king united England long before 1066

Æthelstan, crowned in 925, was the first true king of England but remains overshadowed by Alfred the Great and later rulers. A new biography highlights his military triumphs, legal innovations, and cultural patronage that shaped England’s identity. From the decisive Battle of Brunanburh to his reforms in governance and learning, Æthelstan’s legacy is finally being revived after centuries of neglect.

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AI-powered smart bandage heals wounds 25% faster

A new wearable device, a-Heal, combines AI, imaging, and bioelectronics to speed up wound recovery. It continuously monitors wounds, diagnoses healing stages, and applies personalized treatments like medicine or electric fields. Preclinical tests showed healing about 25% faster than standard care, highlighting potential for chronic wound therapy.

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A tiny mineral may hold the secret to feeding billions sustainably

Rice, a staple for billions, is one of the most resource-hungry crops on the planet—but scientists may have found a way to change that. By applying nanoscale selenium directly to rice plants, researchers dramatically improved nitrogen efficiency, boosted yields, and made grains more nutritious while reducing fertilizer use and cutting greenhouse gas emissions.

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Mushrooms evolved psychedelics twice, baffling scientists

Researchers found that magic mushrooms and fiber caps independently evolved different biochemical pathways to create psilocybin. This convergence shows nature’s ingenuity, but the reason why remains unknown—possibly predator deterrence. Beyond evolutionary mystery, the discovery provides new enzyme tools for biotech, with promising applications for producing psilocybin-based medicines.

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Tylenol in pregnancy linked to higher autism risk, Harvard scientists report

Researchers reviewing 46 studies found evidence linking prenatal acetaminophen (Tylenol) exposure with higher risks of autism and ADHD. The FDA has since urged caution, echoing scientists’ advice that the drug be used only at the lowest effective dose and shortest duration. While important for managing fever and pain in pregnancy, prolonged use may pose risks to fetal development. Experts stress careful medical oversight and further investigation.

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