Discovery of how colorectal cancer drug works will help more patients

Some colorectal cancer patients with a certain gene mutation benefit from a chemotherapy drug called cetuximab, although the mechanism of how this drug worked was unknown. Scientists have combined computational biology with experimental investigations to discover, for the first time, the mechanism for why these patients respond to cetuximab, which will help doctors identify more effective, targeted treatment plans for people diagnosed with colorectal cancer.

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Outcomes of birth options after a previous Cesarean section

A large cohort study of women who have had one or more previous Cesarean sections suggests that attempting a vaginal birth in a subsequent pregnancy is associated with higher health risks to both the mother and the infant than electing for another Cesarean. The research, published in PLOS Medicine on Sept. 24, 2019, addresses a lack of information on the outcomes of birth options after previous cesarean section and can be used to counsel women about their choices.

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Missing electrons reveal the true face of a new copper-based catalyst

New research has resulted in a reactive copper-nitrene catalyst that pries apart carbon-hydrogen (C-H) bonds and transforms them into carbon-nitrogen (C-N) bonds, which are a crucial building block for chemical synthesis, especially in pharmaceutical manufacturing.

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Quality control in immune communication: Chaperones detect immature signaling molecules

The cells of our immune system constantly communicate with one another by exchanging complex protein molecules. A team has now revealed how dedicated cellular control proteins, referred to as chaperones, detect immature immune signaling proteins and prevent them from leaving the cell.

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Most California wildfire is in wildland-urban interface area with less fuel, more people

Homeowner guidance and fire behavior models are largely based on the idea that natural grass, bushes and trees fuel fire in the wildland-urban interface (WUI). Researchers found that over nearly three decades, half of all buildings destroyed by wildfire in California were located in an area of the WUI with less natural vegetation.

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