A massive international study has shown that the experimental oral obesity drug orforglipron can help patients shed over 10% of their body weight, with nearly one in five losing 20% or more. Unlike most GLP-1 agonists that require injections, orforglipron comes as a once-daily pill, potentially making weight-loss treatment more accessible.
Read moreUniversity of Maine researchers developed a new process to make HBL, a key ingredient in many medicines, from renewable glucose instead of petroleum. The approach not only lowers drug production costs but also reduces emissions.
Read moreHepatic insulin resistance, caused by diets high in sugar and fat, can lead to type 2 diabetes. Researchers found that the Elovl6 gene plays a key role in hepatic insulin resistance. Deleting Elov6 in liver cells causes a rise in a specific ceramide lipid that protects mice from hepatic insulin resistance due to excessive dietary sugar. The findings could help efforts to find a targeted treatment for the condition.
Read moreMixtures called alpha-gels are thick, do not flow easily, and can hold much water. Therefore, many skincare products are based on them. A group of scientists from Japan has made an alpha-gel with a compound resembling a main component of the moisture-holding layer on our skin. The characteristics of this alpha-gel indicate that it will make possible environment-friendly and effective skincare products at low energy-costs.
Read morePeople with high blood pressure who take all their anti-hypertensive medication in one go at bedtime have better controlled blood pressure and a significantly lower risk of death or illness caused by heart or blood vessel problems, compared to those who take their medication in the morning, according to new research.
Read moreGenerally, exercise is considered good for you. However, physicians and medical doctors previously prescribed bedrest to people with heart failure, fearing exercise could potentially lead to additional health problems.
Read moreResearchers are giving us double the reasons to pay attention to our cardiovascular health – showing in a recent study that good heart health can equal good brain health.
Read moreFaulty signalling pathway causes the heart to develop unnaturally while in the embryo stage, according to Duke-NUS Medical School researchers.
Read moreWhen young athletes experiences sudden cardiac death as they run down the playing field, it's usually due to arrhythmogenic cardiomyopathy (ACM), an inherited heart disease. Now, researchers have shed new light on the role of the immune system in the progression of ACM and, in the process, discovered a new drug that might help prevent ACM disease symptoms and progression to heart failure in some patients.
Read moreNot all fats are equal in how they affect our skin, according to a new study. The investigators found that different ketogenic diets impacted skin inflammation differently in psoriasiform-like skin inflammation in mice. Ketogenic diets heavy in medium-chain triglycerides (MCTs) such as coconut, especially in combination with omega-3 fatty acids from fish oil and plant sources like nuts and seeds, exacerbated psoriasis.
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