Popular sugar substitute linked to brain cell damage and stroke risk

Erythritol, a widely used sugar substitute found in many low-carb and sugar-free products, may not be as harmless as once believed. New research from the University of Colorado Boulder reveals that even small amounts of erythritol can harm brain blood vessel cells, promoting constriction, clotting, and inflammation—all of which may raise the risk of stroke.

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Three-person DNA IVF stops inherited disease—eight healthy babies born in UK first

In a groundbreaking UK first, eight healthy babies have been born using an IVF technique that includes DNA from three people—two parents and a female donor. The process, known as pronuclear transfer, was designed to prevent the inheritance of devastating mitochondrial diseases passed down through the mother’s DNA. The early results are highly promising: all the babies are developing normally, and the disease-causing mutations are undetectable or present at levels too low to cause harm. For families once haunted by genetic risk, this science offers more than treatment—it offers transformation.

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Obesity exacerbates many causes of death, but risks are different for men and women

People who carry around unhealthy amounts of weight don't just have heart disease and diabetes to worry about. Obesity is implicated in two thirds of the leading causes of death from non-communicable diseases worldwide and the risk of certain diseases differs for men and women.

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Scientists identify new signposts in blood and urine to reflect what we eat and drink

Researchers have identified several chemical signatures, detectable in blood and urine, that can accurately measure dietary intake, potentially offering a new tool for physicians, dieticians and researchers to assess eating habits, measure the value of fad diets and develop health policies.

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Deleting a liver enzyme lowers the health risk of sweet treats (at least in mice)

Hepatic insulin resistance, caused by diets high in sugar and fat, can lead to type 2 diabetes. Researchers found that the Elovl6 gene plays a key role in hepatic insulin resistance. Deleting Elov6 in liver cells causes a rise in a specific ceramide lipid that protects mice from hepatic insulin resistance due to excessive dietary sugar. The findings could help efforts to find a targeted treatment for the condition.

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Reduced food intake in old mice can no longer improve health

Reduced food intake helps both animals and humans to improve health in old age and can prolong life. But when do you have to change your diet to achieve this benefit in old age? Scientists have now shown that mice only become healthier if they start food reduction early and eat less before entering old age. The scientists conclude that healthy behavior must be established earlier in life in order to improve health in old age and extend lifespan.

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A blood factor involved in weight loss and aging

Aging can be delayed through lifestyle changes (physical exercise, restricting calorie intake, etc.). Researchers have elucidated the properties of a molecule in the blood – GDF11 – whose mechanisms were previously unknown. In a mouse model, they showed that this molecule could mimic the benefits of certain calorie restrictions – dietary regimens that have proven their efficacy in reducing cardiovascular disease, preventing cancer and increasing neurogenesis in the brain.

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Training parents is key to helping children eat a variety of foods

Families dealing with the stress and frustration of their child's overly picky eating habits may have a new addition to their parental toolbox. Pediatric researchers recently described a brief group cognitive-behavioral therapy program that provides parents with specific techniques to improve their child's mealtime behaviors and expand the range of foods their children will eat. Although the study size was small, the parents involved reported 'life-changing' improvements.

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Limiting mealtimes may increase your motivation for exercise

Limiting access to food in mice increases levels of the hormone, ghrelin, which may also increase motivation to exercise, according to a new study. The study suggests that a surge in levels of appetite-promoting hormone, ghrelin, after a period of fasting prompted mice to initiate voluntary exercise.

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