Treating pulmonary embolism: How safe and effective are new devices?

A new scientific statement identifies the risks and benefits of novel interventional devices compared to anticoagulation alone in the treatment of patients with pulmonary embolism. Authors conclude there is little data — particularly, as it pertains to the treatment of patients with 'intermediate-risk PE' — that suggests these interventional approaches are more safe and effective than the use of anticoagulation alone.

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Scientists ID new targets to treat fibrosis, a feature of many chronic diseases

When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term — but bad when myofibroblast activation gets out of hand. Now, researchers show how fibroblast activation and myofibroblast formation occurs, providing clues for how to target fibrosis — which impacts several chronic diseases.

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Ibrutinib linked to high blood pressure and other heart problems, study suggests

Over half of people prescribed the targeted blood cancer-fighting drug ibrutinib developed new or worsened high blood pressure within six months of starting the medication. The analysis is also the first to tie ibrutinib-related hypertension to a heightened risk of heart problems, particularly atrial fibrillation. Moreover, the association of ibrutinib with cardiovascular complications remained regardless of the prescribed dose.

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Potential drug to treat heart attacks

Administered within hours of an attack, the potential drug would prevent scarring that can lead to heart failure. For the study, the researcher used a drug that targets a key component of the cellular clock mechanism. The medication disrupts expression of genes that trigger adverse immune responses after a heart attack. When mice were given the drug after a heart attack, they were found to have less inflammation and improved cardiac repair.

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