The 'Goldilocks' principle for curing brain cancer
Researchers found that a stable body temperature holds the key to awakening the body's immune response to fight off brain cancer.
Read moreLymphoma
Targeting certain rogue T cells prevents and reverses multiple sclerosis in mice
Multiple sclerosis, an autoimmune disorder, is known to be driven by 'helper' T cells, white blood cells that mount an inflammatory attack on the brain and spinal cord. A new study pinpoints the specific subgroup of helper T cells that cause MS, as well as a protein on their surface, called CXCR6, that marks them. An antibody targeting CXCR6 both prevented and reversed MS in a mouse model, the researchers report.
Read moreTargeting regulator of mitochondrial cell death delivers anticancer activity
A novel anticancer molecule created by researchers showed therapeutic activity in preclinical models of various cancer types.
Read moreStem cell studies offer hope for childhood neurological condition
Two new studies report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease (PMD), a rare genetic condition affecting boys that can be fatal before 10 years of age.
Read moreNew method to purify cell types to high purity
Current biology research relies on the ability to purify cell types using antibodies or transgenic constructs. However, antibody availability is often limited, and genetic manipulation is labor intensive or sometimes impossible. To date, no universal method exists to enrich for cell types without a priori knowledge of cell type markers. Here, we propose GateID, a computational method that combines single-cell transcriptomics with FACS index sorting to purify cell types using only native cellular properties.
Read moreParkinson's disease is also present in the blood
The behavior of immune cells in the blood is so different in patients with Parkinson's disease that it advocate for a new type of supplementary medicine, which can regulate the immune system and thus inhibit the deterioration of the brain.
Read more'Dietary' vulnerability found in cancer cells with mutated spliceosomes
A research team has discovered a metabolic vulnerability in multiple types of cancer cells that bear a common genetic mutation affecting cellular machines called spliceosomes.
Read moreCancer data provide insights into occurrence, overdiagnosis, and treatment advances
Investigators analyzed 40 years of cancer burden data and examined patterns of incidence and mortality for various cancers, finding examples for which incidence and mortality moved in concert and examples where discordance in incidence and mortality indicate that overdiagnosis may be at play.
Read moreMutant cells team up to make an even deadlier blood cancer
Two very different mutations have been identified as unexpected partners in crime for causing the blood cancer acute myeloid leukemia (AML). Expert analysis from CSHL helped reveal how this deadly duo is far more common in AML than thought.
Read moreEnvironmental toxins impair immune system over multiple generations
New research shows that maternal exposure to a common and ubiquitous form of industrial pollution can harm the immune system of offspring and that this injury is passed along to subsequent generations, weakening the body's defenses against infections such as the influenza virus.
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