Engineered T cells may be harnessed to kill solid tumor cells
A new study finds that a form of immunotherapy used to treat the blood cancer leukemia may be effective in treating other kinds of cancer as well.
Read moreLymphoma
Immune therapy eliminates tumor cells in early triple negative breast cancer
Immune therapy added to chemotherapy improves pathological complete response in patients with early triple negative breast cancer, according to new results from the KEYNOTE-522 trial. Interim results from the study, which is the first phase III trial of immunotherapy in early breast cancer, also indicated an improvement in event-free survival.
Read moreA new mechanism has been revealed which could lead to premature aging in mother cells
A new mechanism makes it possible to understand premature ageing in cells with asymmetrical cell division, as is the case with mother cells. Understanding this mechanism is useful for studying and, in the future, anticipating the development of ageing-related diseases, such as cancer and neurodegenerative processes.
Read moreNew biofabrication method creates one scaffold to guide regeneration of multiple tissues
Scientists have taken a major step to address the challenge of engineer tissues organized like native tissues. They have demonstrated a new method to fabricate scaffolds presenting spatially organized cues to control cell behavior locally within one material.
Read moreHow newly found tension sensor plays integral role in aligned chromosome partitioning
New research found that oncogene SET/TAF1, which was found to be a proto-oncogene of acute myeloid leukemia (AML), contributes to proper chromosome partitioning as a tension sensor. Additionally, abnormal SET protein disrupts tension sensor system at the centromere, leading to missegregation of the chromosomes and thereby cancer. These findings may lead to a discovery for a new kind of leukemia treatment.
Read moreTasmanian devil research could help tackle immunotherapy resistance
A cluster of interacting proteins that are active in both human cancers and Tasmanian devil facial tumours, may give clues to how cancers evade the immune system, according to a new study.
Read moreResearchers uncover molecular changes associated with treating lymphatic filariasis
The Global Program to Eliminate Lymphatic Filariasis delivers mass drug administration to 500 million people each year, and adverse events are common following treatment. Now, researchers have reported that certain changes in gene expression are associated with these adverse events.
Read moreHuman kidney map charts our growing immune defense
The first cell atlas of the human kidney's immune system has been created after scientists mapped nearly 70,000 individual kidney cells from early life and adults. Researchers generated the atlas and used it to map immune cells in the kidney. This shows for the first time how the kidney's immune system develops during early life, and strengthens after birth and as we mature into adults, with implications for tackling kidney disease and transplant rejection.
Read moreHow neural circuits form in a developing embryo
A new imaging method follows young neurons in a developing embryo as they progress from a messy jumble of cells into a coordinated control center. The approach lets scientists track development and emerging cell function simultaneously across entire circuits.
Read moreHow time affects the fate of stem cells
Scientists have discovered how temporal fluctuations in the levels of two transcription factors can push embryonic stems cells into becoming different cell types.
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