Potential target for cardiac fibrosis treatment

A research team has identified a potential target for treating heart failure related to fibrosis. The study looked at an epigenetic 'reader' protein known as BRD4, showing that it serves a central role in regulating the activation of cardiac fibroblasts. They also found that chemical inhibitors of BRD4 potently block cardiac fibroblast activation.

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Scientists create fully electronic 2-dimensional spin transistors

Physicists have constructed a two-dimensional spin transistor, in which spin currents were generated by an electric current through graphene. A monolayer of a transition metal dichalcogenide (TMD) was placed on top of graphene to induce charge-to-spin conversion in the graphene.

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Elusive compounds of greenhouse gas isolated

Nitrous oxide (N2O) is a potent atmospheric pollutant. Although naturally occurring, anthropogenic N2O emissions from intensive agricultural fertilization, industrial processes, and combustion of fossil fuels and biomass are a major cause for concern. Researchers have isolated elusive transition metal compounds of N2O that provide clues into how it could be used in sustainable chemical technologies.

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One way childhood trauma leads to poorer health for women

Researchers have long known that childhood trauma is linked to poorer health for women at midlife. A new study shows one important reason why. The national study of more than 3,000 women is the first to find that those who experienced childhood trauma were more likely than others to have their first child both earlier in life and outside of marriage – and that those factors were associated with poorer health later in life.

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Gene editing enables researchers to correct mutation in muscle stem cells in DMD model

Duchenne muscular dystrophy (DMD) is a rare but devastating genetic disorder that causes muscle loss and physical impairments. Researchers have shown in a mouse study that the powerful gene editing technique known as CRISPR may provide the means for lifelong correction of the genetic mutation responsible for the disorder.

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Fungicides as an underestimated hazard for freshwater organisms

Large amounts of fungicides, used in agriculture, leak into nearby surface waters. The effects of it on aquatic organisms are poorly understood and not specifically addressed in the EU regulatory frameworks with respect to the protection of surface waters. Scientists have found that pollution by fungicides can have unforeseen but far-reaching consequences for the functioning of aquatic systems — like indirect effects on the development of algal blooms.

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