New mechanism in the liver helps prevent invasive fungal infections

An expert in intravital microscopy is making breakthroughs in invasive fungal infections. He has discovered a pathway by which liver macrophages capture fungi before dissemination to target organs like the brain. This not only provides an explanation as to why individuals with liver disease have enhanced risk of fungal infection, but also points to therapeutic options to prevent these infections, which kill 1.5 million people annually.

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Common denominator that triggers asthma in favorable environments

Some so-called pro-allergic environments strongly promote the development of asthma and are responsible for the dramatic increase in the prevalence of asthma, especially in industrialized countries. Researchers at the GIGA of the University of Liège have identified how all these pro-allergic environments act in the same way on the pulmonary immune system to induce the development of allergic asthma.

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Long-term study data shows DBS is effective treatment for most severe form of depression

Deep brain stimulation (DBS) of an area in the brain called the subcallosal cingulate (SCC) provides a robust antidepressant effect that is sustained over a long period of time in patients with treatment-resistant depression — the most severely depressed patients who have not responded to other treatments.

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Tension around autonomy increases family conflict at end of life

Conflict within families can be stressful and confusing, and it can lead to feelings of sadness. It also is incredibly common and in many cases, a necessary part of family dynamics. New research highlights how caregivers can better manage family conflict as they deal with the approaching death of a loved one.

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Potential drug to treat heart attacks

Administered within hours of an attack, the potential drug would prevent scarring that can lead to heart failure. For the study, the researcher used a drug that targets a key component of the cellular clock mechanism. The medication disrupts expression of genes that trigger adverse immune responses after a heart attack. When mice were given the drug after a heart attack, they were found to have less inflammation and improved cardiac repair.

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Most kidney transplants between people with HIV have long-term success

People living with HIV who received kidney transplants from deceased donors with HIV had high rates of overall survival and kidney graft survival after five years, according to an observational study. The investigators followed 51 study participants with HIV who received kidney transplants from deceased donors with HIV in South Africa.

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