By collaborating globally in a new, large-scale effort, researchers have made strong progress in sequencing genomes from regions and countries across Africa. These findings will enable more broadly representative and relevant studies ranging from basic through clinical genetics.
Read moreResearchers have implicated 10 new genes in the development of schizophrenia using a method called whole exome sequencing, the analysis of the portion of DNA that codes for proteins. A global consortium of schizophrenia research teams incorporated genetic data from over 125,000 people to gain deeper insights into the genetic underpinnings of schizophrenia.
Read moreA new study points to the need for better antibody validation, and outlines a process that other labs can use to make sure the antibodies they work with function properly.
Read moreScientists have developed a molecular 'clock' that could reshape how pediatricians measure and monitor childhood growth and potentially allow for an earlier diagnosis of life-altering development disorders.
Read moreNew insights into how the molecular organization of charged molecules can be regulated to transform large-scale structures from ribbons to scroll-like cochleate structures could inform future drug-delivery strategies.
Read moreA multi-institutional team has brought attention to genomic structural variation as a previously unappreciated mechanism involved in altering DNA methylation, a form of gene control, in human cancers.
Read moreThe new method is leading to a better understanding of natural protein modifications and improved protein therapeutics.
Read moreThe technique makes use of the fact that people inherit two copies or ''alleles'' of virtually every gene, one from the mother and one from the father. The new method compares activity levels of maternal and paternal alleles across the genome and detects when the activity of an allele lies far enough outside the normal range to be a plausible cause of disease.
Read moreSome forms of sudden infant death syndrome stem from a genetic mutation that keeps infants from processing lipids in milk, a new study has discovered. The build-up of unprocessed fatty material disrupts heart functions. While no treatments are yet available, the finding could help in genetic screening. Drugs are also being tested to see if they can help.
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