New method provides better understanding of gene 'enhancers' work

Using anew method called Net-CAGE, researchers identified as many as 20,000 new enhancers in humans. They found that while promoters are activated in a variety of cell types, enhancers tend to function in just 1 cell type, thus showing an important difference between the 2 types of region.

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New CRISPR class expands genetic engineering toolbox

Biomedical engineers have used a previously unexplored CRISPR technology to accurately regulate and edit target genes in human cells. With this new approach, the researchers hope to dramatically expand the CRISPR-based tools available to biomedical engineers, opening up a new and diverse frontier of genome engineering technologies.

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Some parents pass on more mutations to their children than others

Everyone is a mutant but some are prone to diverge more than others, report scientists. A new study shows the number of mutations a child has compared to her parents varies dramatically with some people being born with twice as many as others, and that characteristic runs in families.

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DNA is held together by hydrophobic forces

Researchers have disproved the prevailing theory of how DNA binds itself. It is not, as is generally believed, hydrogen bonds which bind together the 2 sides of the DNA structure. Instead, water is the key. The discovery opens doors for new understanding in research in medicine and life sciences.

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Genomic migration analysis shows antibiotic resistance moving from humans to animals

New results show that human-acquired antibiotic resistance genes are being transmitted to livestock, companion animals and wildlife. Researchers analyzed a global set of 901 genome sequences of the bacteria Streptococcus agalactiae (aka group B Strep) from nine different host species — humans, cows, dogs, fish, frogs, gray seals, dolphins, goats and a camel — to better understand the transmission process. Streptococcus agalactiae can cause life-threatening illnesses.

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