Study pinpoints Alzheimer's plaque emergence early and deep in the brain

By scanning whole brains of Alzheimer's model mice from an early age, researchers were able to precisely trace the terrible march of amyloid plaques from deep brain structures outward along specific circuits. They also showed that plaque density in a key region in humans scales with disease stage.

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Printed electronics open way for electrified tattoos and personalized biosensors

Electrical engineers have devised a fully print-in-place technique for printable electronics that is gentle enough to work on delicate surfaces ranging from paper to human skin. This can be accomplished without additional steps to bake, wash or powder-coat materials. The advance could enable technologies such as high-adhesion, embedded electronic tattoos and bandages with patient-specific biosensors.

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Fragmented physical activity linked to greater mortality risk

Although reduced physical activity during the day is widely seen as a harbinger of mortality in older people, fragmentation of physical activity — spreading daily activity across more episodes of brief activity — may be an earlier indicator of mortality risk than total amount of daily activity, according to a new study.

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Chair yoga more effective than music therapy in older adults with advanced dementia

Researchers assessed the ability of older adults with advanced dementia to participate in non-pharmacological interventions and compared chair yoga with chair-based exercise and music therapy. Results showed that participants with moderate-to-severe dementia could safely adhere to non-pharmacological interventions; more than 97 percent fully engaged in each session. The chair yoga group reported a higher quality of life score, including physical condition, mood, functional abilities, interpersonal relationships, and ability to participate in meaningful activities.

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