Scientists describe a previously unknown disorder of the immune system: in a distinct subset of immune cells from patients with primary immunodeficiency, cellular respiration is significantly increased. This cellular metabolic overactivity leads to inflammation.
Read moreThe way immune cells pick friends from foes can be described by a classic maths puzzle known as the 'narrow escape problem'.
Read moreScientists have fine-tuned their delivery system to deliver a DNA editing tool to alter DNA sequences and modify gene function. The improved 'hit and run' system works faster and is more efficient.
Read moreIt's long been known that our immune cells mix and match bits of genetic code to make new kinds of antibodies to fight newly encountered threats. But how these different gene segments come together has been a mystery. A study provides the answer, showing how the classic process of V(D)J recombination makes use of chromatin looping to gather the segments to be spliced.
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