Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of ''ammunition'' because of more and more frequently occurring resistances. Research teams have now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to development of innovative antibiotics which target the degradation process of defective proteins in bacteria.
Read moreWhen it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term — but bad when myofibroblast activation gets out of hand. Now, researchers show how fibroblast activation and myofibroblast formation occurs, providing clues for how to target fibrosis — which impacts several chronic diseases.
Read moreResearchers have discovered how the enzyme DNA polymerase delta works to duplicate the genome that cells hand down from one generation to the next.
Read moreResearchers have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage and could be important for the emerging field of regenerative medicine.
Read moreScientists have created the most accurate 3D model yet of an intrinsically disordered protein, revealing the ensemble of its atomic-level structures.
Read moreDeoxyribonucleic acid (DNA), is the macromolecule that holds all hereditary and genetic information. Continuously under assault, alterations and damage to DNA can lead to many different health issues, including cancer. DNA is highly regulated within cells, where multiple mechanisms are at play to repair and protect its integrity. Scientists are still investigating these mechanisms to fully comprehend how these DNA repair processes are managed. Researchers recently identified a new mechanism that controls DNA repair.
Read moreNew research shows there is more at play than just a sinking feeling when you stumble during movement or trip in a hole in the ground.
Read moreBefore the French Revolution, family trees were reserved for the feudal upper classes, who used them to consolidate their social status. While feudalism broke down and family trees lost their old roles, the trees gained new functions as scientific models.
Read moreThe Great Alaskan Earthquake of 1964 and the tsunamis it spawned may have washed a tropical fungus ashore, leading to a subsequent outbreak of often-fatal infections among people in coastal regions of the Pacific Northwest, according to a new article.
Read moreA small genetic study identified a protein linked to many genetic variants that affect heart function. Researchers are expanding the model to other organ systems and at larger scales to create a broader understanding of genes and proteins involved.
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