Research maps key signaling pathways linking calcium entry and exit in activated T cells

Like entrance and exit doors on a building, a cell's outer surface has doors — channels, pumps, and transporters that selectively control what molecules enter or exit. In the immune system, T cells possess unique sets of 'doors', including ones that specialize in calcium ion movement. Now, researchers describe a unique mechanism for coordinating these calcium entrance and exit 'doors' on T cells that helps them carry out their jobs and ensure normal immune function.

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Common denominator that triggers asthma in favorable environments

Some so-called pro-allergic environments strongly promote the development of asthma and are responsible for the dramatic increase in the prevalence of asthma, especially in industrialized countries. Researchers at the GIGA of the University of Liège have identified how all these pro-allergic environments act in the same way on the pulmonary immune system to induce the development of allergic asthma.

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From sleeping cell to assassin — how immune cells work

Scientists have carried out one of the most comprehensive studies into how immune cells sense and respond to their environment to fight infection and destroy tumors. The research team said the results provide important insights into how immune responses might be manipulated for the treatment of autoimmune diseases and cancer.

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Scientists find timekeepers of gut's immune system

Shift work and jet lag disrupt not just sleep cycles, but feeding and digestive cycles as well. Such disruptions have been linked to risk of obesity, inflammatory bowel disease, infection, and other conditions. Now, researchers have identified an immune cell that helps set the daily rhythms of the gut. The findings open the door to new treatments for digestive ailments targeting such cells.

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Scientist designs 'express courier service' for immune cells

A researcher who is currently doing his post-doctoral training at Stanford University, has successfully invented a novel transfection method to deliver DNA into immune cells with minimal stress on these cells. This new technique is expected to boost DNA-based cancer immunotherapy by significantly improving the process of generating high-quality genetically modified immune cells.

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New defensive mechanism against bacterial wound infections

Wound inflammation which results in impaired wound healing can have serious consequences for patients. Researchers have discovered a new defensive mechanism which enables our skin to actively kill bacteria. Central to this mechanism is a cellular messenger molecule known as 'interleukin 6', whose mode of action may be used in the future to prevent wound infections.

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