Hidden brain signal reveals Alzheimer’s years before symptoms

A new study has revealed that TSPO, a protein linked to brain inflammation, rises long before Alzheimer’s symptoms appear. Researchers tracked the protein in genetically engineered mice and confirmed the results in human brain tissue from Colombian families with a known Alzheimer’s mutation. They found unusually high levels of TSPO in microglia clustered around plaques, particularly in women. This discovery not only deepens our understanding of the disease but also sparks the possibility of using TSPO to detect and treat Alzheimer’s far earlier than ever before.

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Schizophrenia risk gene linked to cognitive deficits in mice

Researchers have discovered in mice how one of the few genes definitively linked to schizophrenia, called SETD1A, likely confers risk for the illness. Mice genetically engineered to lack a functioning version of the enzyme-coding gene showed abnormalities in working memory, mimicking those commonly seen in patients. Restoring the gene's function corrected the working memory deficit and counteracting its deficiency also repaired neuronal circuit deficits in adult mice — suggesting clues for potential treatment strategies.

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A new discovery: How our memories stabilize while we sleep

Scientists have shown that delta waves emitted while we sleep are not generalized periods of silence during which the cortex rests, as has been described for decades in the scientific literature. Instead, they isolate assemblies of neurons that play an essential role in long-term memory formation.

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Beyond the 'replication crisis,' does research face an 'inference crisis'?

For the past decade, social scientists have been unpacking a 'replication crisis' that has revealed how findings of an alarming number of scientific studies are difficult or impossible to repeat. Efforts are underway to improve the reliability of findings, but cognitive psychology researchers say that not enough attention has been paid to the validity of theoretical inferences made from research findings.

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