Discovered new regulation for infant growth
Researchers have identified new genetic signals for the regulation of how infants grow. This may be a crucial step in the fight against growth-related diseases.
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Three-in-one inhaler therapy can improve lung function and reduce asthma attacks
Patients with severe asthma which is not controlled with standard treatment — leaving them at risk of severe asthma attacks — could benefit from using a single inhaler combining three, instead of 2 therapies, according to two phase 3 randomized controlled trials with over 2,500 patients across 17 countries.
Read moreFruit flies live longer with combination drug treatment
A triple drug combination has been used to extend the lifespan of fruit flies by 48% in a new study.
Read moreFirst prostate cancer therapy to target genes delays cancer progression
For the first time, prostate cancer has been treated based on the genetic makeup of the cancer, resulting in delayed disease progression, delayed time to pain progression, and potentially extending lives in patients with advanced, metastatic prostate cancer, reports a large phase 3 trial. This marks a significant advance for prostate cancer treatment, which has lagged behind other common cancers with regard to precision therapy, now the standard of care in breast, ovarian and lung cancers.
Read moreSkin-cells-turned-to-heart-cells help unravel genetic underpinnings of cardiac function
A small genetic study identified a protein linked to many genetic variants that affect heart function. Researchers are expanding the model to other organ systems and at larger scales to create a broader understanding of genes and proteins involved.
Read moreFirst targeted therapy for cholangiocarcinoma shows clinical benefit in phase III trial
New data have shown for the first time that targeted therapy can improve the outcome of patients diagnosed with advanced cholangiocarcinoma. Cholangiocarcinoma is a subtype of bile duct cancer with aggressive behavior and poor prognosis. Despite the low incidence, most patients die from the disease and therefore new effective therapies are urgently needed.
Read moreHandgun purchasers with a prior DUI have a greater risk for serious violence
Legal purchasers of handguns with a prior DUI conviction have a greater risk of a future arrest for a violent offense — including murder, rape, robbery, and aggravated assault and for firearm-related violent crimes.
Read moreWhole genome sequencing could enable personalized cancer treatment
Whole genome sequencing of tumour cells could help predict the prognosis of a patient's cancer and offer clues to identify the most effective treatment, suggests an international study.
Read moreResearchers advance search for safer, easier way to deliver vision-saving gene therapy
In experiments with rats, pigs and monkeys, researchers have developed a way to deliver sight-saving gene therapy to the retina. If proved safe and effective in humans, the technique could provide a new, more permanent therapeutic option for patients with common diseases such as wet age-related macular degeneration (AMD), and it could potentially replace defective genes in patients with inherited retinal disease.
Read moreNew AI method may boost Crohn's disease insight and improve treatment
Scientists have developed a computer method that may help improve understanding and treatment of Crohn's disease, which causes inflammation of the digestive tract. The study used artificial intelligence to examine genetic signatures of Crohn's in 111 people. The method revealed previously undiscovered genes linked to the disease, and accurately predicted whether thousands of other people had the disease.
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