Personalized Medicine – Page 9 – PossibleThreat Articles

African American children respond differently to asthma medications

September 27, 2019 0 Comments Allergy, Asthma, Chronic Illness, Diseases and Conditions, Mental Health Research, Multiple Sclerosis Research, Personalized Medicine, Sickle Cell Anemia

African Americans suffer asthma more often and more severely than Caucasian patients. However, clinical trials that have shaped treatment guidelines have included few African Americans. A new report demonstrates a shortcoming of that history. Researchers report that African American children respond differently than African American adults and Caucasian adults and children to step-up therapies for inadequately controlled asthma.

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Genomic map implicates broad immune cell involvement in multiple sclerosis

September 27, 2019 0 Comments Brain-Computer Interfaces, Child Development, Diseases and Conditions, Disorders and Syndromes, Immune System, Multiple Sclerosis, Multiple Sclerosis Research, Personalized Medicine

In a study of 115,803 individuals, the authors have identified 233 sites or loci in the human genome that contribute to the onset of MS. This is the largest study to date in MS.

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Researchers uncover molecular changes associated with treating lymphatic filariasis

September 26, 2019 0 Comments Diseases and Conditions, Genes, Human Biology, Immune System, Lymphoma, Medical Topics, Personalized Medicine, Pharmacology

The Global Program to Eliminate Lymphatic Filariasis delivers mass drug administration to 500 million people each year, and adverse events are common following treatment. Now, researchers have reported that certain changes in gene expression are associated with these adverse events.

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Trial finds high-dose radiation effective for men whose prostate cancer has spread

September 26, 2019 0 Comments Breast Cancer, Diseases and Conditions, Men's Health, Personalized Medicine, Prostate Cancer, Prostate Health, Today's Healthcare, Urology

A randomized clinical trial of targeted, high-dose radiation for men with oligometastatic prostate cancer has shown the treatment to be an effective and safe option for patients who wish to delay hormone-suppression therapy. The phase II trial found that radiation therapy can generate an immune system response not previously believed possible in this type of cancer.

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Scientists tackle potential drug resistance by using new single-cell genetic method

September 25, 2019 0 Comments Brain Tumor, Cancer, Diabetes, HIV and AIDS, Lung Cancer, Personalized Medicine, Pharmaceuticals, Pharmacology

Using a new technique that can identify genetic profiles of individual cells, researchers modeled a breast cancer tumor's potential resistance to a drug, and then identified a drug combination that reversed that resistance.

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Researchers developing new 'DNA stitch' to treat muscular dystrophy

September 25, 2019 0 Comments Diseases and Conditions, Gene Therapy, Genes, Human Biology, Muscular Dystrophy, Neuropathy, Personalized Medicine, Today's Healthcare

A new therapeutic being tested is showing early promise as a more effective treatment that could help nearly half of patients with Duchenne muscular dystrophy (DMD). The treatment — a cocktail of DNA-like molecules — results in dramatic regrowth of a protein called dystrophin, which acts as a support beam to keep muscles strong. The protein is virtually absent in those with DMD.

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Mystery underlying heart toxicity caused by diabetes drugs solved

September 25, 2019 0 Comments Cholesterol, Diabetes, Diseases and Conditions, Heart Disease, Hypertension, Personalized Medicine, Pharmacology, Vioxx

For new diabetes medications, in which one drug aims to address the excess of lipids and glucose in the blood, the therapeutic benefits, while great, frequently are accompanied by dangerous toxic effects to the heart. Why and how these drugs cause heart dysfunction in diabetes patients has been unclear. Now, scientists show that certain diabetes drugs have a profound toxic effect on the generation and function of mitochondria.

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New method provides better understanding of gene 'enhancers' work

September 25, 2019 0 Comments Brain Tumor, Cancer, Diseases and Conditions, Genes, Human Biology, Lung Cancer, Personalized Medicine, Stem Cells

Using anew method called Net-CAGE, researchers identified as many as 20,000 new enhancers in humans. They found that while promoters are activated in a variety of cell types, enhancers tend to function in just 1 cell type, thus showing an important difference between the 2 types of region.

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New CRISPR class expands genetic engineering toolbox

September 24, 2019 0 Comments Biology, Biotechnology, Biotechnology and Bioengineering, CRISPR Gene Editing, Genes, Human Biology, Medical Topics, Personalized Medicine

Biomedical engineers have used a previously unexplored CRISPR technology to accurately regulate and edit target genes in human cells. With this new approach, the researchers hope to dramatically expand the CRISPR-based tools available to biomedical engineers, opening up a new and diverse frontier of genome engineering technologies.

News Science

Improved mapping of Swedish genes

September 24, 2019 0 Comments Cancer, Diseases and Conditions, Forensics, Genes, Human Biology, Medical Topics, Personalized Medicine, Viruses

People — or more specifically just Swedes — are more like chimpanzees than previously known. This is indicated in a genetic mapping of one thousand Swedish individuals, where new DNA sequences that should be included in the reference genome have been identified.