Walking slower and pausing for rest may enable older adults to maintain outdoor mobility
The potential positive, enabling, effects of walking modifications should also be considered when older people's functional ability declines.
Read moreChronic Illness
Kidney disease: Senescent cell burden is reduced in humans by senolytic drugs
In a small safety and feasibility clinical trial, researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed 'senolytics.' The result was verified not only in analysis of blood but also in changes in skin and fat tissue senescent cell abundance.
Read morePotential target for cardiac fibrosis treatment
A research team has identified a potential target for treating heart failure related to fibrosis. The study looked at an epigenetic 'reader' protein known as BRD4, showing that it serves a central role in regulating the activation of cardiac fibroblasts. They also found that chemical inhibitors of BRD4 potently block cardiac fibroblast activation.
Read moreFeeling depressed? Mahjong might be the answer
When it comes to boosting mental health among older Chinese, it might be as simple as a game of mahjong, according to a new study.
Read moreEnvironmental toxin produced by algae may lead to ALS
A computer generated-simulation allowed researchers to see how a toxin produced by algal blooms in saltwater might cause Amyotrophic Lateral Sclerosis (ALS).
Read moreCause of rare, fatal disorder in young children pinpointed
Scientists appear to have solved a decades-long mystery regarding the precise biochemical pathway leading to a fatal genetic disorder in children that results in seizures, developmental regression and death, usually around age 3. Studying a mouse model with the same human illness — called Krabbe disease — the researchers also identified a possible therapeutic strategy.
Read moreMore than Lyme: Tick study finds multiple agents of tick-borne diseases
Scientists reported on the prevalence of multiple agents capable of causing human disease that are present in three species of ticks in Long Island.
Read moreDefective cilia linked to heart valve birth defects
Bicuspid aortic valve (BAV), the most common heart valve birth defect, is associated with genetic variation in human primary cilia during heart valve development, report researchers. Crucial to cilia development is the exocyst, which shuttles cilia cargo to the cell membrane. Disrupting the exocyst impaired ciliogenesis and caused a spectrum of cardiac defects in zebrafish and BAV in mice.
Read moreFor kids who face trauma, good neighbors or teachers can save their longterm health
New research shows just how important positive childhood experiences are for long-term health, especially for those who experience significant adversity as a child. Studies over the past 20 years have found a correlation between adverse childhood events (such as death or divorce) and worse health outcomes later in life. A new study discovers that positive childhood experiences, like having good neighbors, or a teacher you trust, have the potential to negate harmful health effects caused by adverse childhood experiences.
Read moreStarting HIV treatment in ERs may be key to ending HIV spread worldwide
Researchers say they have evidence that hospital emergency departments (EDs) worldwide may be key strategic settings for curbing the spread of HIV infections in hard-to-reach populations if the EDs jump-start treatment and case management as well as diagnosis of the disease.
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