Three-dimensional structure of the genome replication machine discovered
Researchers have discovered how the enzyme DNA polymerase delta works to duplicate the genome that cells hand down from one generation to the next.
Read moreGenes
New neurodevelopmental syndrome and NKAP gene
Researchers have identified a gene mutation that causes developmental delay, intellectual disability, behavioral abnormalities and musculoskeletal problems in children. The newly diagnosed condition, called NKAP-related syndrome, arises from mutations in the NKAP gene, which plays a key role in human development.
Read moreBreakthrough in sex-chromosome regulation
Researchers have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage and could be important for the emerging field of regenerative medicine.
Read moreTreatment for familial adenomatous polyposis
Researchers have developed an innovative drug treatment for familial adenomatous polyposis (FAP), a rare, inherited condition that affects adolescents and young adults and often leads to colorectal cancer.
Read moreSupercomputing, neutrons unite to unravel structures of intrinsically disordered protein
Scientists have created the most accurate 3D model yet of an intrinsically disordered protein, revealing the ensemble of its atomic-level structures.
Read moreMutant cells team up to make an even deadlier blood cancer
Two very different mutations have been identified as unexpected partners in crime for causing the blood cancer acute myeloid leukemia (AML). Expert analysis from CSHL helped reveal how this deadly duo is far more common in AML than thought.
Read moreA new route to blocking children's bone cancer
A study in mice showed that reducing a particular hormone signal keeps the cancer from growing and spreading.
Read moreNew mechanism controlling DNA repair identified
Deoxyribonucleic acid (DNA), is the macromolecule that holds all hereditary and genetic information. Continuously under assault, alterations and damage to DNA can lead to many different health issues, including cancer. DNA is highly regulated within cells, where multiple mechanisms are at play to repair and protect its integrity. Scientists are still investigating these mechanisms to fully comprehend how these DNA repair processes are managed. Researchers recently identified a new mechanism that controls DNA repair.
Read moreResearchers create new viral vector for improved gene therapy in sickle cell disease
Researchers have developed a new and improved viral vector — a virus-based vehicle that delivers therapeutic genes — for use in gene therapy for sickle cell disease. In advanced lab tests using animal models, the new vector was up to 10 times more efficient at incorporating corrective genes into bone marrow stem cells than the conventional vectors currently used, and it had a carrying capacity of up to six times higher, the researchers report.
Read moreMolecular motors: Rotation on an eight-shaped path
Chemical engineers have developed the first molecular motor that enables an eight-shaped movement.
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