Three-dimensional structure of the genome replication machine discovered
Researchers have discovered how the enzyme DNA polymerase delta works to duplicate the genome that cells hand down from one generation to the next.
Read moreGenetics
Protein associated with many diseases fully visualized for first time
For the first time, researchers have learned at the molecular level how the P2X7 protein receptor – which is associated with inflammation, coronary artery disease, cancer, multiple sclerosis and more – works. The findings could one day inspire new drugs to treat numerous medical conditions.
Read moreBreakthrough in sex-chromosome regulation
Researchers have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage and could be important for the emerging field of regenerative medicine.
Read moreHow the Texas puma saved the Florida panther
Scientists have pieced together the first complete picture of the Florida panther genome — work that could serve to protect that endangered population and other endangered species going forward.
Read moreNew method to purify cell types to high purity
Current biology research relies on the ability to purify cell types using antibodies or transgenic constructs. However, antibody availability is often limited, and genetic manipulation is labor intensive or sometimes impossible. To date, no universal method exists to enrich for cell types without a priori knowledge of cell type markers. Here, we propose GateID, a computational method that combines single-cell transcriptomics with FACS index sorting to purify cell types using only native cellular properties.
Read moreSupercomputing, neutrons unite to unravel structures of intrinsically disordered protein
Scientists have created the most accurate 3D model yet of an intrinsically disordered protein, revealing the ensemble of its atomic-level structures.
Read moreMutant cells team up to make an even deadlier blood cancer
Two very different mutations have been identified as unexpected partners in crime for causing the blood cancer acute myeloid leukemia (AML). Expert analysis from CSHL helped reveal how this deadly duo is far more common in AML than thought.
Read moreHow AIDS pathogens multiply in the body
Scientists have now succeeded in using high-resolution imaging to make visible to the millisecond how the HI virus spreads between living cells and which molecules it requires for this purpose. The researchers provide direct proof for the first time that the AIDS pathogen creates a certain lipid environment for replication.
Read moreCRISPRed fruit flies mimic monarch butterfly, and could make you vomit
Monarch butterflies and a few other insects evolved essentially the same genetic mutations allowing them to eat toxic milkweed without getting sick. Monarch butterflies and caterpillars store the toxins to deter predators. Scientists have now used CRISPR gene editing to make these same mutations in fruit flies, successfully conferring toxin resistance. This is the first time an animal has been genetically engineered to eat a new food and employ a new type of deterrence.
Read moreNew mechanism controlling DNA repair identified
Deoxyribonucleic acid (DNA), is the macromolecule that holds all hereditary and genetic information. Continuously under assault, alterations and damage to DNA can lead to many different health issues, including cancer. DNA is highly regulated within cells, where multiple mechanisms are at play to repair and protect its integrity. Scientists are still investigating these mechanisms to fully comprehend how these DNA repair processes are managed. Researchers recently identified a new mechanism that controls DNA repair.
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