The cells of our immune system constantly communicate with one another by exchanging complex protein molecules. A team has now revealed how dedicated cellular control proteins, referred to as chaperones, detect immature immune signaling proteins and prevent them from leaving the cell.
Read moreThe biological clock influences immune response efficacy. Indeed, CD8 T cells, which are essential to fight infections and cancers, function very differently according to the time of day.
Read moreFor the first time ever, researchers have mapped how bacterial cells trigger their defense against outside attacks. This could affect how diseases are fought in the future.
Read moreCells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. Researchers have identified 44 specific senescence-associated proteins that are involved in blood clotting, marking the first time that cellular senescence has been associated with age-related blood clots.
Read moreIn experiments with mice, researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method suppressed the growth of multiple types of human tumors that had been transplanted into the animals.
Read moreA new platform brings together CRISPR genome editing with magnetic cell sorting to reveal new drug targets for cancer and regenerative medicine.
Read moreResearchers have found that dogs can suffer from the same type of autoimmune encephalitis that people do. The finding could lead to better screening methods for diagnosis and possibly more effective treatments for canine encephalitis.
Read moreResearchers have used a technique called high-throughput mutagenesis to study Amyotrophic Lateral Sclerosis (ALS), with unexpected results. Results showed that aggregation of TDP-43 is not harmful but actually protects cells, changing our understanding of ALS and opening the door to radically new therapeutic approaches.
Read moreResearchers have identified a previously unknown mechanism that regulates release of insulin, a hormone that lowers blood glucose levels, from the beta cells of the pancreas. This mechanism is disrupted in type 2 diabetes. The scientists hope this finding will be used to develop new treatments against the disease.
Read moreA new study details a possible solution for fine-tuning inflammation and cellular activity in cardiac recovery — thanks to an antibody initially developed for rheumatoid arthritis.
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