Three-dimensional structure of the genome replication machine discovered
Researchers have discovered how the enzyme DNA polymerase delta works to duplicate the genome that cells hand down from one generation to the next.
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Treatment for familial adenomatous polyposis
Researchers have developed an innovative drug treatment for familial adenomatous polyposis (FAP), a rare, inherited condition that affects adolescents and young adults and often leads to colorectal cancer.
Read moreSubstantial variation in uptake of new prescribing guidance by GPs
Substantial variation exists between general practices in uptake of new prescribing guidance, with important implications for patient care and health expenditure, finds the largest analysis of its kind.
Read moreLaser therapy gains credibility as effective option for treating vaginal problems
Nearly 50% of menopausal women complain of vaginal dryness, itching, and burning, among other commonly reported menopause symptoms. Laser therapy is one of the newer techniques for addressing these problems. A new study suggests that it is as effective and safe as vaginal estrogen in improving sexual and urinary functionality.
Read moreA new route to blocking children's bone cancer
A study in mice showed that reducing a particular hormone signal keeps the cancer from growing and spreading.
Read moreAntidepressant medications appear to be generally safe,study suggests
Antidepressants are generally safe, according to a new study. By assessing evidence from 45 meta-analyses, which combined the results from many studies, the researchers did not find strong evidence of adverse health outcomes associated with antidepressant use.
Read moreBiomarker in urine may offer noninvasive detection of prostate cancer
A research study has identified a novel prostate cancer gene fusion involving the KLK4 protein coding gene and KLKP1 pseudogene. This unique biomarker can be detected in the urine samples of patients with prostate cancer, offering a non-invasive means of detection.
Read moreNew mechanism controlling DNA repair identified
Deoxyribonucleic acid (DNA), is the macromolecule that holds all hereditary and genetic information. Continuously under assault, alterations and damage to DNA can lead to many different health issues, including cancer. DNA is highly regulated within cells, where multiple mechanisms are at play to repair and protect its integrity. Scientists are still investigating these mechanisms to fully comprehend how these DNA repair processes are managed. Researchers recently identified a new mechanism that controls DNA repair.
Read moreDoctor offers unique perspective as father of a child with rare genetic disease
From a professional standpoint, Nathan Hoot, MD, Ph.D., understands the value of medical research that leads to new, groundbreaking drugs in the treatment of rare diseases. And as an emergency medicine physician, he's familiar with adjusting ventilators and managing patients' airways. But the magnitude of these matters also weigh on Hoot personally — as the father of a child with a rare genetic disease.
Read moreStem cell treatments for shoulder and elbow injuries flourish, but so far there's little evidence they work
Two critical reviews examine the current status of biologic approaches for common shoulder and elbow problems. The authors discuss areas where the current evidence base is weak or controversial and recommend where further studies are required.
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