Targeting certain rogue T cells prevents and reverses multiple sclerosis in mice

Multiple sclerosis, an autoimmune disorder, is known to be driven by 'helper' T cells, white blood cells that mount an inflammatory attack on the brain and spinal cord. A new study pinpoints the specific subgroup of helper T cells that cause MS, as well as a protein on their surface, called CXCR6, that marks them. An antibody targeting CXCR6 both prevented and reversed MS in a mouse model, the researchers report.

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Sinking groundwater levels threaten the vitality of riverine ecosystems

Groundwater is the world's largest source of freshwater and it is of vital importance for food production. Increasing extraction of groundwater in recent decades has resulted in sinking water tables worldwide. A study by a hydrologist shows that almost 20 percent of the catchments areas where groundwater is pumped suffer from a flow that is too low to sustain freshwater ecosystems. This number is expected to increase to 50 percent by 2050.

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Determining the activity of noble-metal-free catalyst particles

Chemists have developed a new method with which they can characterize individual noble-metal-free nanoparticle catalysts. The particles could be a cheap alternative to precious metal catalysts for obtaining hydrogen from water by means of electrolysis.

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Analysis of HIV-1B in Indonesia illuminates transmission dynamics of the virus

Research into the molecular phylogeny (evolutionary history) of the HIV-1B virus in Indonesia has succeeded in illuminating the transmission period and routes for three clades (main branches of the virus). This includes a clade thought to be unique to Indonesia, as well as clades that spread from Thailand, Europe and America in the 1970s and 1980s.

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New fluorescence method reveals signatures of individual microbes

Researchers have developed a new method that reveals the unique fluorescence patterns produced by individual cells in mixtures of bacteria, yeast and fungi. They combined confocal microscopy with micro-spectroscopy to determine the fluorescence signatures from different types of microbes. They trained machine learning systems to analyze the images and identify different individual cells and cell-types automatically, even those with very similar shapes and sizes.

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Twin baby stars grow amongst a twisting network of gas and dust

Astronomers have obtained an extremely high-resolution image showing two disks in which young stars are growing, fed by a complex pretzel-shaped network of filaments of gas and dust. Observing this remarkable phenomenon sheds new light on the earliest phases of the lives of stars and helps astronomers determine the conditions in which binary stars are born.

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Scientists create brain-mimicking environment to grow 3D tissue models of brain tumors

Researchers have developed 3-dimensional human tissue culture models of pediatric and adult brain cancers in a brain-mimicking microenvironment, that includes brain-derived extracellular matrix (ECM) — the complex network of proteins and amino acids with bound sugars that not only provides support for surrounding neural tissue, but also helps to guide cell growth and development. The development represents a significant advancement for the study of brain tumor biology and pharmacological response.

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