Machine learning's next frontier: Epigenetic drug discovery

Scientists have developed a machine-learning algorithm that gleans information from microscope images — allowing for high-throughput epigenetic drug screens that could unlock new treatments for cancer, heart disease, mental illness and more.

Read more

Preventing streptococci infections

Researchers have discovered an enzyme they believe could be key to preventing Group A Streptococcus infections that cause more than 500,000 deaths worldwide each year. The enzyme works through a novel mechanism of action that can also be found in other streptococcal species, increasing the impact and relevance of this finding.

Read more

A simpler way to make some medicines

Organic chemists have figured out how to synthesize the most common molecule arrangement in medicine, a scientific discovery that could change the way a number of drugs — including one most commonly used to treat ovarian cancer — are produced. Their discovery, published today in the journal Chem, gives drug makers a crucial building block for creating medicines that, so far, are made with complex processes that result in a lot of waste.

Read more

Parasite paralysis: A new way to fight schistosomiasis?

Scientists have isolated a natural chemical that acts as a potent kryptonite against parasitic worms that burrow through human skin and cause devastating health problems. Researchers now describe the successful characterization of this chemical, which could help in finding new ways to fight the neglected tropical disease schistosomiasis.

Read more

Paclitaxel-coated devices are safe for unblocking arteries in lower limbs, study suggests

A study of nearly 65,000 people suggests that devices coated with a drug called paclitaxel that are used for widening blocked arteries in legs and feet are safe and not linked to an increase in deaths — a finding that contradicts smaller studies that led to the FDA issuing a safety alert about the use of paclitaxel-coated stents and balloons for arterial revascularization in the lower limbs in January 2019.

Read more