Supercomputing, neutrons unite to unravel structures of intrinsically disordered protein
Scientists have created the most accurate 3D model yet of an intrinsically disordered protein, revealing the ensemble of its atomic-level structures.
Read moreCell Biology
Earthquake in the cell
Nuclear abnormalities such as nuclear blebs and micronuclei have devastating consequences for the genetic material and are associated with cancer or ageing. Scientists now revealed that the epigenetic enzyme MOF is crucial for the morphological integrity of the mammalian nucleus. Moreover, the study characterized the epigenetic landscape of nuclear abnormalities and discovered a formerly unknown epigenetic mechanism that seems to protect cells from additional damage.
Read moreGene responsible for lutein esterification in bread wheat identified
Researchers have identified and confirmed the gene responsible for lutein esterification in bread wheat. The activity of this gene controls the timing of esterification in grain, which is related to storage and nutritional qualities of bread wheat and other grains.
Read moreCollagen fibers encourage cell streaming through balancing act
Engineers have shown that the length of collagen fibers has a roll to play in the ability of normal cells to become invasive.
Read moreCracking how tardigrades survive the extremes
Scientists have gained a new understanding of how tiny, ultra-resilient invertebrates known as tardigrades, or 'water bears,' are protected in extreme conditions. Tardigrades are found in water environments around the world — including mountainous, deep sea and Antarctic environments. The researchers discovered that a tardigrade protein named Dsup binds to chromatin — DNA inside cells — and forms a protective cloud against extreme survival threats such as radiation damage.
Read moreJellyfish's 'superpowers' gained through cellular mechanism
Jellyfish are animals that possess the unique ability to regenerate body parts. A team of scientists has now revealed the cellular mechanisms that give jellyfish these remarkable 'superpowers.'
Read morePotent antibody curbs Nipah and Hendra virus attack
A monoclonal antibody has been shown to impede the fusion machinery henipaviruses use to merge with the membrane of cells they are attempting to breach. The antibody halts the attack by blocking membrane fusion and the injection of the viral genome into the host cell. Researchers hope this discovery will pave the way toward preventing or treating Nipah or Hendra virus infections, which now have no vaccines or therapies for people. The main carriers are large bats called flying foxes.
Read morePoorly reported placebos could lead to mistaken estimates of benefits and harms
Researchers have found that placebo controls are almost never described according to standard reporting guidelines.
Read moreUltrasound can reveal gene expression in the body
Researchers are developing a technique for imaging mammalian gene expression with ultrasound by combining human bacteria and virus DNA.
Read moreSpider silk: A malleable protein provides reinforcement
Scientists have discovered that spider silk contains an exceptional protein. It generates high bonding strength by making use of an amino acid scientists have hitherto paid little attention to. The finding could have important implications in many areas.
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