Researchers have discovered an enzyme they believe could be key to preventing Group A Streptococcus infections that cause more than 500,000 deaths worldwide each year. The enzyme works through a novel mechanism of action that can also be found in other streptococcal species, increasing the impact and relevance of this finding.
Read moreOrganic chemists have figured out how to synthesize the most common molecule arrangement in medicine, a scientific discovery that could change the way a number of drugs — including one most commonly used to treat ovarian cancer — are produced. Their discovery, published today in the journal Chem, gives drug makers a crucial building block for creating medicines that, so far, are made with complex processes that result in a lot of waste.
Read moreScientists have isolated a natural chemical that acts as a potent kryptonite against parasitic worms that burrow through human skin and cause devastating health problems. Researchers now describe the successful characterization of this chemical, which could help in finding new ways to fight the neglected tropical disease schistosomiasis.
Read moreScientists have uncovered a novel antibiotic-free approach that could help prevent and treat one of the most widespread bacterial pathogens, using nanocapsules made of natural ingredients.
Read moreDespite humanity's best efforts to eradicate malaria, the disease struck more than 200 million people in 2017, according to the World Health Organization. Worse yet, the parasite that causes malaria is developing resistance to many antimalarial drugs, including the mainstay, chloroquine. Researchers are actively searching for new treatments, and now, a group have found that acaí berry extracts can reduce parasites in the blood and prolong the survival of infected mice.
Read moreA new study reveals that commonly given hip and knee steroid intra-articular injections may be harmful in some patients with at-risk conditions or may cause complications that are not well understood.
Read moreResearchers have developed a machine learning system that may be able to warn doctors and patients about possible negative side effects that might occur when drugs are mixed.
Read moreA research team found muscle cells treated with statins released the amino acid called glutamate at much higher levels than muscle cells that were untreated. As glutamate is a potent activator of muscle pain receptors, this release was proposed to trigger the sensation of muscle pain.
Read moreNew insights into how the molecular organization of charged molecules can be regulated to transform large-scale structures from ribbons to scroll-like cochleate structures could inform future drug-delivery strategies.
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